The emerging of telemedicine, diagnostic AI, tracking and wearable technologies as well as the influence of big data has stimulated the growth of Health Tech start-ups all over the world. But to be a Health Tech Start-up is not an easy journey. There is a big need for professional support and the right ecosystems to assure successful solutions and products that will go to market and become successful. The role of Startup accelerators is to support early-stage, growth-driven companies through, among others, education, mentorship, financing and network. How can they make the difference for Health Tech Start-ups?